Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

We studied the effect of microtubule-associated tau protein on trafficking of vesicles and organelles in primary cortical neurons, retinal ganglion cells, and neuroblastoma cells. Tau inhibits kinesin-dependent transport of peroxisomes, neurofilaments, and Golgi-derived vesicles into neurites. Loss...

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Detalles Bibliográficos
Autores principales: Stamer, K., Vogel, R., Thies, E., Mandelkow, E., Mandelkow, E.-M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173473/
https://www.ncbi.nlm.nih.gov/pubmed/11901170
http://dx.doi.org/10.1083/jcb.200108057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173473/
https://www.ncbi.nlm.nih.gov/pubmed/11901170
http://dx.doi.org/10.1083/jcb.200108057

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