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Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
We studied the effect of microtubule-associated tau protein on trafficking of vesicles and organelles in primary cortical neurons, retinal ganglion cells, and neuroblastoma cells. Tau inhibits kinesin-dependent transport of peroxisomes, neurofilaments, and Golgi-derived vesicles into neurites. Loss...
Autores principales: | Stamer, K., Vogel, R., Thies, E., Mandelkow, E., Mandelkow, E.-M. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173473/ https://www.ncbi.nlm.nih.gov/pubmed/11901170 http://dx.doi.org/10.1083/jcb.200108057 |
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