Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

Activation of the serine/threonine kinase Akt/PKB positively impacts on three cellular processes relevant to tumor progression: proliferation, survival, and cell size/growth. Using a three-dimensional culture model of MCF-10A mammary cells, we have examined how Akt influences the morphogenesis of po...

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Detalles Bibliográficos
Autores principales: Debnath, Jayanta, Walker, Stephanie J., Brugge, Joan S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173511/
https://www.ncbi.nlm.nih.gov/pubmed/14568991
http://dx.doi.org/10.1083/jcb.200304159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173511/
https://www.ncbi.nlm.nih.gov/pubmed/14568991
http://dx.doi.org/10.1083/jcb.200304159

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