Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality

Tropomodulin1 (Tmod1) caps thin filament pointed ends in striated muscle, where it controls filament lengths by regulating actin dynamics. Here, we investigated myofibril assembly and heart development in a Tmod1 knockout mouse. In the absence of Tmod1, embryonic development appeared normal up to em...

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Detalles Bibliográficos
Autores principales: Fritz-Six, Kimberly L., Cox, Patrick R., Fischer, Robert S., Xu, Bisong, Gregorio, Carol C., Zoghbi, Huda Y., Fowler, Velia M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173615/
https://www.ncbi.nlm.nih.gov/pubmed/14657235
http://dx.doi.org/10.1083/jcb.200308164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173615/
https://www.ncbi.nlm.nih.gov/pubmed/14657235
http://dx.doi.org/10.1083/jcb.200308164

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