SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase

Nerve growth factor (NGF) mediates the survival and differentiation of neurons by stimulating the tyrosine kinase activity of the TrkA/NGF receptor. Here, we identify SHP-1 as a phosphotyrosine phosphatase that negatively regulates TrkA. SHP-1 formed complexes with TrkA at Y490, and dephosphorylated...

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Detalles Bibliográficos
Autores principales: Marsh, H. Nicholas, Dubreuil, Catherine I., Quevedo, Celia, Lee, Anna, Majdan, Marta, Walsh, Gregory S., Hausdorff, Sharon, Said, Farid Arab, Zoueva, Olga, Kozlowski, Maya, Siminovitch, Katherine, Neel, Benjamin G., Miller, Freda D., Kaplan, David R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173621/
https://www.ncbi.nlm.nih.gov/pubmed/14662744
http://dx.doi.org/10.1083/jcb.200309036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173621/
https://www.ncbi.nlm.nih.gov/pubmed/14662744
http://dx.doi.org/10.1083/jcb.200309036

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