Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers

L-selectin is a key lectin essential for leukocyte capture and rolling on vessel walls. Functional adhesion of L-selectin requires a minimal threshold of hydrodynamic shear. Using high temporal resolution videomicroscopy, we now report that L-selectin engages its ligands through exceptionally labile...

Descripción completa

Detalles Bibliográficos
Autores principales: Dwir, Oren, Solomon, Ariel, Mangan, Shmuel, Kansas, Geoffrey S., Schwarz, Ulrich S., Alon, Ronen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173661/
https://www.ncbi.nlm.nih.gov/pubmed/14597772
http://dx.doi.org/10.1083/jcb.200303134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173661/
https://www.ncbi.nlm.nih.gov/pubmed/14597772
http://dx.doi.org/10.1083/jcb.200303134

Ejemplares similares