Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition

Caenhorhabditis elegans Unc104 kinesin transports synaptic vesicles at rapid velocities. Unc104 is primarily monomeric in solution, but recent motility studies suggest that it may dimerize when concentrated on membranes. Using cryo-electron microscopy, we observe two conformations of microtubule-bou...

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Detalles Bibliográficos
Autores principales: Al-Bassam, Jawdat, Cui, Yujia, Klopfenstein, Dieter, Carragher, Bridget O., Vale, Ronald D., Milligan, Ronald A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173678/
https://www.ncbi.nlm.nih.gov/pubmed/14638858
http://dx.doi.org/10.1083/jcb.200308020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173678/
https://www.ncbi.nlm.nih.gov/pubmed/14638858
http://dx.doi.org/10.1083/jcb.200308020

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