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Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane
Although the transport of model proteins across the mammalian ER can be reconstituted with purified Sec61p complex, TRAM, and signal recognition particle receptor, some substrates, such as the prion protein (PrP), are inefficiently or improperly translocated using only these components. Here, we pur...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173754/ https://www.ncbi.nlm.nih.gov/pubmed/12578908 http://dx.doi.org/10.1083/jcb.200210095 |