Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

Granzyme B (GrB), acting similar to an apical caspase, efficiently activates a proteolytic cascade after intracellular delivery by perforin. Studies here were designed to learn whether the physiologic effector, GrB–serglycin, initiates apoptosis primarily through caspase-3 or through BH3-only protei...

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Detalles Bibliográficos
Autores principales: Metkar, Sunil S., Wang, Baikun, Ebbs, Michelle L., Kim, Jin H., Lee, Yong J., Raja, Srikumar M., Froelich, Christopher J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173758/
https://www.ncbi.nlm.nih.gov/pubmed/12629051
http://dx.doi.org/10.1083/jcb.200210158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173758/
https://www.ncbi.nlm.nih.gov/pubmed/12629051
http://dx.doi.org/10.1083/jcb.200210158

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