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Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis
Granzyme B (GrB), acting similar to an apical caspase, efficiently activates a proteolytic cascade after intracellular delivery by perforin. Studies here were designed to learn whether the physiologic effector, GrB–serglycin, initiates apoptosis primarily through caspase-3 or through BH3-only protei...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173758/ https://www.ncbi.nlm.nih.gov/pubmed/12629051 http://dx.doi.org/10.1083/jcb.200210158 |