The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling

CD148 is a receptor-like protein tyrosine phosphatase up-regulated on T cells after T cell receptor (TCR) stimulation. To examine the physiologic role of CD148 in TCR signaling, we used an inducible CD148-expressing Jurkat T cell clone. Expression of CD148 inhibits NFAT (nuclear factor of activated...

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Detalles Bibliográficos
Autores principales: Lin, Joseph, Weiss, Arthur
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173795/
https://www.ncbi.nlm.nih.gov/pubmed/12913111
http://dx.doi.org/10.1083/jcb.200303040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173795/
https://www.ncbi.nlm.nih.gov/pubmed/12913111
http://dx.doi.org/10.1083/jcb.200303040

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