Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane

Amyloid β-peptide (Aβ) is generated by the consecutive cleavages of β- and γ-secretase. The intramembraneous γ-secretase cleavage critically depends on the activity of presenilins (PS1 and PS2). Although there is evidence that PSs are aspartyl proteases with γ-secretase activity, it remains controve...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaether, Christoph, Lammich, Sven, Edbauer, Dieter, Ertl, Michaela, Rietdorf, Jens, Capell, Anja, Steiner, Harald, Haass, Christian
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173840/
https://www.ncbi.nlm.nih.gov/pubmed/12147673
http://dx.doi.org/10.1083/jcb.200201123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173840/
https://www.ncbi.nlm.nih.gov/pubmed/12147673
http://dx.doi.org/10.1083/jcb.200201123

Ejemplares similares