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The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA–GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
We have studied the formation of different types of cell matrix adhesions in cells that bind to fibronectin via either α5β1 or αvβ3. In both cases, cell adhesion to fibronectin leads to a rapid decrease in RhoA activity. However, α5β1 but not αvβ3 supports high levels of RhoA activity at later stage...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173988/ https://www.ncbi.nlm.nih.gov/pubmed/12486108 http://dx.doi.org/10.1083/jcb.200205014 |