Human TPX2 is required for targeting Aurora-A kinase to the spindle

Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a prominent component of the spindle apparatus. TPX2 was identified by mass spectrometry as a major protein coimmunoprecipitating specifically with...

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Detalles Bibliográficos
Autores principales: Kufer, Thomas A., Silljé, Herman H.W., Körner, Roman, Gruss, Oliver J., Meraldi, Patrick, Nigg, Erich A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174010/
https://www.ncbi.nlm.nih.gov/pubmed/12177045
http://dx.doi.org/10.1083/jcb.200204155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174010/
https://www.ncbi.nlm.nih.gov/pubmed/12177045
http://dx.doi.org/10.1083/jcb.200204155

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