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Huntingtin toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

The cause of Huntington's disease is expansion of polyglutamine (polyQ) domain in huntingtin, which makes this protein both neurotoxic and aggregation prone. Here we developed the first yeast model, which establishes a direct link between aggregation of expanded polyQ domain and its cytotoxicit...

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Detalles Bibliográficos
Autores principales: Meriin, Anatoli B., Zhang, Xiaoqian, He, Xiangwei, Newnam, Gary P., Chernoff, Yury O., Sherman, Michael Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174031/
https://www.ncbi.nlm.nih.gov/pubmed/12058016
http://dx.doi.org/10.1083/jcb.200112104