Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells

The activity of serum response factor (SRF), an essential transcription factor in mouse gastrulation, is regulated by changes in actin dynamics. Using Srf(−/−) embryonic stem (ES) cells, we demonstrate that SRF deficiency causes impairments in ES cell spreading, adhesion, and migration. These defect...

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Detalles Bibliográficos
Autores principales: Schratt, Gerhard, Philippar, Ulrike, Berger, Jürgen, Schwarz, Heinz, Heidenreich, Olaf, Nordheim, Alfred
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174087/
https://www.ncbi.nlm.nih.gov/pubmed/11839767
http://dx.doi.org/10.1083/jcb.200106008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174087/
https://www.ncbi.nlm.nih.gov/pubmed/11839767
http://dx.doi.org/10.1083/jcb.200106008

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