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Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells
The activity of serum response factor (SRF), an essential transcription factor in mouse gastrulation, is regulated by changes in actin dynamics. Using Srf(−/−) embryonic stem (ES) cells, we demonstrate that SRF deficiency causes impairments in ES cell spreading, adhesion, and migration. These defect...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174087/ https://www.ncbi.nlm.nih.gov/pubmed/11839767 http://dx.doi.org/10.1083/jcb.200106008 |