Cargando…
Mg(2+) Enhances Voltage Sensor/Gate Coupling in BK Channels
BK (Slo1) potassium channels are activated by millimolar intracellular Mg(2+) as well as micromolar Ca(2+) and membrane depolarization. Mg(2+) and Ca(2+) act in an approximately additive manner at different binding sites to shift the conductance–voltage (G(K)-V) relation, suggesting that these ligan...
Autores principales: | Horrigan, Frank T., Ma, Zhongming |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174156/ https://www.ncbi.nlm.nih.gov/pubmed/18166624 http://dx.doi.org/10.1085/jgp.200709877 |
Ejemplares similares
-
A gating lever and molecular logic gate that couple voltage and calcium sensor activation to opening in BK potassium channels
por: Sun, Liang, et al.
Publicado: (2022) -
Role of Charged Residues in the S1–S4 Voltage Sensor of BK Channels
por: Ma, Zhongming, et al.
Publicado: (2006) -
An Extracellular Cu(2+) Binding Site in the Voltage Sensor of BK and Shaker Potassium Channels
por: Ma, Zhongming, et al.
Publicado: (2008) -
Coupling between Voltage Sensor Activation, Ca(2+) Binding and Channel Opening in Large Conductance (BK) Potassium Channels
por: Horrigan, Frank T., et al.
Publicado: (2002) -
Cysteine Modification Alters Voltage- and Ca(2+)-dependent Gating of Large Conductance (BK) Potassium Channels
por: Zhang, Guangping, et al.
Publicado: (2005)