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Disuse-induced Preferential Loss of the Giant Protein Titin Depresses Muscle Performance via Abnormal Sarcomeric Organization

Persistent muscle weakness due to disuse-associated skeletal muscle atrophy limits the quality of life for patients with various diseases and individuals who are confined to bed. Fibers from disused muscle exhibit a marked reduction in active force production, which can exacerbate motor function, co...

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Detalles Bibliográficos
Autores principales: Udaka, Jun, Ohmori, Shintaro, Terui, Takako, Ohtsuki, Iwao, Ishiwata, Shin'ichi, Kurihara, Satoshi, Fukuda, Norio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174161/
https://www.ncbi.nlm.nih.gov/pubmed/18166625
http://dx.doi.org/10.1085/jgp.200709888