Glycosylation Can Influence Topogenesis of Membrane Proteins and Reveals Dynamic Reorientation of Nascent Polypeptides within the Translocon

The topology of multispanning membrane proteins in the mammalian endoplasmic reticulum is thought to be dictated primarily by the first hydrophobic sequence. We analyzed the in vivo insertion of a series of chimeric model proteins containing two conflicting signal sequences, i.e., an NH(2)-terminal...

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Detalles Bibliográficos
Autores principales: Goder, Veit, Bieri, Christoph, Spiess, Martin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174215/
https://www.ncbi.nlm.nih.gov/pubmed/10525533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174215/
https://www.ncbi.nlm.nih.gov/pubmed/10525533

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