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A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool
Neuregulin-1 provides an important axonally derived signal for the survival and growth of developing Schwann cells, which is transmitted by the ErbB2/ErbB3 receptor tyrosine kinases. Null mutations of the neuregulin-1, erbB2, or erbB3 mouse genes cause severe deficits in early Schwann cell developme...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174554/ https://www.ncbi.nlm.nih.gov/pubmed/10704452 |
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author | Garratt, Alistair N. Voiculescu, Octavian Topilko, Piotr Charnay, Patrick Birchmeier, Carmen |
author_facet | Garratt, Alistair N. Voiculescu, Octavian Topilko, Piotr Charnay, Patrick Birchmeier, Carmen |
author_sort | Garratt, Alistair N. |
collection | PubMed |
description | Neuregulin-1 provides an important axonally derived signal for the survival and growth of developing Schwann cells, which is transmitted by the ErbB2/ErbB3 receptor tyrosine kinases. Null mutations of the neuregulin-1, erbB2, or erbB3 mouse genes cause severe deficits in early Schwann cell development. Here, we employ Cre-loxP technology to introduce erbB2 mutations late in Schwann cell development, using a Krox20-cre allele. Cre-mediated erbB2 ablation occurs perinatally in peripheral nerves, but already at E11 within spinal roots. The mutant mice exhibit a widespread peripheral neuropathy characterized by abnormally thin myelin sheaths, containing fewer myelin wraps. In addition, in spinal roots the Schwann cell precursor pool is not correctly established. Thus, the Neuregulin signaling system functions during multiple stages of Schwann cell development and is essential for correct myelination. The thickness of the myelin sheath is determined by the axon diameter, and we suggest that trophic signals provided by the nerve determine the number of times a Schwann cell wraps an axon. |
format | Text |
id | pubmed-2174554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21745542008-05-01 A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool Garratt, Alistair N. Voiculescu, Octavian Topilko, Piotr Charnay, Patrick Birchmeier, Carmen J Cell Biol Original Article Neuregulin-1 provides an important axonally derived signal for the survival and growth of developing Schwann cells, which is transmitted by the ErbB2/ErbB3 receptor tyrosine kinases. Null mutations of the neuregulin-1, erbB2, or erbB3 mouse genes cause severe deficits in early Schwann cell development. Here, we employ Cre-loxP technology to introduce erbB2 mutations late in Schwann cell development, using a Krox20-cre allele. Cre-mediated erbB2 ablation occurs perinatally in peripheral nerves, but already at E11 within spinal roots. The mutant mice exhibit a widespread peripheral neuropathy characterized by abnormally thin myelin sheaths, containing fewer myelin wraps. In addition, in spinal roots the Schwann cell precursor pool is not correctly established. Thus, the Neuregulin signaling system functions during multiple stages of Schwann cell development and is essential for correct myelination. The thickness of the myelin sheath is determined by the axon diameter, and we suggest that trophic signals provided by the nerve determine the number of times a Schwann cell wraps an axon. The Rockefeller University Press 2000-03-06 /pmc/articles/PMC2174554/ /pubmed/10704452 Text en © 2000 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Original Article Garratt, Alistair N. Voiculescu, Octavian Topilko, Piotr Charnay, Patrick Birchmeier, Carmen A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool |
title | A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool |
title_full | A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool |
title_fullStr | A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool |
title_full_unstemmed | A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool |
title_short | A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool |
title_sort | dual role of erbb2 in myelination and in expansion of the schwann cell precursor pool |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174554/ https://www.ncbi.nlm.nih.gov/pubmed/10704452 |
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