Formation of Spindle Poles by Dynein/Dynactin-Dependent Transport of Numa

NuMA is a large nuclear protein whose relocation to the spindle poles is required for bipolar mitotic spindle assembly. We show here that this process depends on directed NuMA transport toward microtubule minus ends powered by cytoplasmic dynein and its activator dynactin. Upon nuclear envelope brea...

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Detalles Bibliográficos
Autores principales: Merdes, Andreas, Heald, Rebecca, Samejima, Kumiko, Earnshaw, William C., Cleveland, Don W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174573/
https://www.ncbi.nlm.nih.gov/pubmed/10811826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174573/
https://www.ncbi.nlm.nih.gov/pubmed/10811826

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