Oncogenic K-Ras and Basic Fibroblast Growth Factor Prevent FAS-Mediated Apoptosis in Fibroblasts through Activation of Mitogen-Activated Protein Kinase

By an expression cloning method using Fas-transgenic Balb3T3 cells, we tried to obtain inhibitory genes against Fas-mediated apoptosis and identified proto-oncogene c-K-ras. Transient expression of K-Ras mutants revealed that oncogenic mutant K-Ras (RasV12) strongly inhibited, whereas dominant-inhib...

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Detalles Bibliográficos
Autores principales: Kazama, Hirotaka, Yonehara, Shin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174806/
https://www.ncbi.nlm.nih.gov/pubmed/10662780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174806/
https://www.ncbi.nlm.nih.gov/pubmed/10662780

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