Downregulation of 14-3-3σ Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes

In human epidermal keratinocytes, replicative senescence, is determined by a progressive decline of clonogenic and dividing cells. Its timing is controlled by clonal evolution, that is, by the continuous transition from stem cells to transient amplifying cells. We now report that downregulation of 1...

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Detalles Bibliográficos
Autores principales: Dellambra, Elena, Golisano, Osvaldo, Bondanza, Sergio, Siviero, Emanuela, Lacal, Pedro, Molinari, Marta, D'Atri, Stefania, De Luca, Michele
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174818/
https://www.ncbi.nlm.nih.gov/pubmed/10831615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174818/
https://www.ncbi.nlm.nih.gov/pubmed/10831615

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