Inhibitors of Copi and Copii Do Not Block PEX3-Mediated Peroxisome Synthesis

In humans, defects in peroxisome biogenesis are the cause of lethal diseases typified by Zellweger syndrome. Here, we show that inactivating mutations in human PEX3 cause Zellweger syndrome, abrogate peroxisome membrane synthesis, and result in reduced abundance of peroxisomal membrane proteins (PMP...

Descripción completa

Detalles Bibliográficos
Autores principales: South, Sarah T., Sacksteder, Katherine A., Li, Xiaoling, Liu, Yifei, Gould, Stephen J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175136/
https://www.ncbi.nlm.nih.gov/pubmed/10871277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175136/
https://www.ncbi.nlm.nih.gov/pubmed/10871277

Ejemplares similares