Defining Fibronectin's Cell Adhesion Synergy Site by Site-Directed Mutagenesis

Fibronectin's RGD-mediated binding to the α5β1 integrin is dramatically enhanced by a synergy site within fibronectin III domain 9 (FN9). Guided by the crystal structure of the cell-binding domain, we selected amino acids in FN9 that project in the same direction as the RGD, presumably toward t...

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Detalles Bibliográficos
Autores principales: Redick, Sambra D., Settles, Daniel L., Briscoe, Gina, Erickson, Harold P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175162/
https://www.ncbi.nlm.nih.gov/pubmed/10769040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175162/
https://www.ncbi.nlm.nih.gov/pubmed/10769040

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