Mutation of a Major Keratin Phosphorylation Site Predisposes to Hepatotoxic Injury in Transgenic Mice

Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate filament (IF) proteins. One important physiologic function of K8/18 is to protect hepatocytes from drug-induced liver injury. Although the mechanism of this protection is unknown, marked K8/18 hyperphosphorylation occu...

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Detalles Bibliográficos
Autores principales: Ku, Nam-On, Michie, Sara A., Soetikno, Roy M., Resurreccion, Evelyn Z., Broome, Rosemary L., Omary, M. Bishr
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Regular Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175212/
https://www.ncbi.nlm.nih.gov/pubmed/9864372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175212/
https://www.ncbi.nlm.nih.gov/pubmed/9864372

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