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Mutation of a Major Keratin Phosphorylation Site Predisposes to Hepatotoxic Injury in Transgenic Mice
Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate filament (IF) proteins. One important physiologic function of K8/18 is to protect hepatocytes from drug-induced liver injury. Although the mechanism of this protection is unknown, marked K8/18 hyperphosphorylation occu...
Autores principales: | Ku, Nam-On, Michie, Sara A., Soetikno, Roy M., Resurreccion, Evelyn Z., Broome, Rosemary L., Omary, M. Bishr |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175212/ https://www.ncbi.nlm.nih.gov/pubmed/9864372 |
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