Deficiency of RecA-dependent RecFOR and RecBCD pathways causes increased instability of the (GAA·TTC)(n) sequence when GAA is the lagging strand template

The most common mutation in Friedreich ataxia is an expanded (GAA·TTC)(n) sequence, which is highly unstable in human somatic cells and in the germline. The mechanisms responsible for this genetic instability are poorly understood. We previously showed that cloned (GAA·TTC)(n) sequences replicated i...

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Detalles Bibliográficos
Autores principales: Pollard, Laura M., Chutake, Yogesh K., Rindler, Paul M., Bidichandani, Sanjay I.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175318/
https://www.ncbi.nlm.nih.gov/pubmed/17932052
http://dx.doi.org/10.1093/nar/gkm810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175318/
https://www.ncbi.nlm.nih.gov/pubmed/17932052
http://dx.doi.org/10.1093/nar/gkm810

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