Sinefungin resistance of Saccharomyces cerevisiae arising from sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase

The S-adenosylmethionine (AdoMet) analog sinefungin is a natural product antibiotic that inhibits nucleic acid methyltransferases and arrests the growth of unicellular eukarya and eukaryal viruses. The basis for the particular sensitivity of fungi and protozoa to sinefungin is not known. Here we rep...

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Detalles Bibliográficos
Autores principales: Zheng, Sushuang, Shuman, Stewart, Schwer, Beate
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175321/
https://www.ncbi.nlm.nih.gov/pubmed/17932050
http://dx.doi.org/10.1093/nar/gkm817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175321/
https://www.ncbi.nlm.nih.gov/pubmed/17932050
http://dx.doi.org/10.1093/nar/gkm817

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