Trans-lesion synthesis and RNaseH activity by reverse transcriptases on a true abasic RNA template

While much is known about abasic DNA, the biological impact of abasic RNA is largely unexplored. To test the mutagenic potential of this RNA lesion in the context of retroviruses, we synthesized a 31-mer oligoribonucleotide containing an abasic (rAS) site and used it as a template for studying DNA p...

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Detalles Bibliográficos
Autores principales: Küpfer, Pascal A., Crey-Desbiolles, Caroline, Leumann, Christian J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175328/
https://www.ncbi.nlm.nih.gov/pubmed/17932068
http://dx.doi.org/10.1093/nar/gkm767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175328/
https://www.ncbi.nlm.nih.gov/pubmed/17932068
http://dx.doi.org/10.1093/nar/gkm767

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