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Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation
The Escherichia coli AlkB protein catalyzes the direct reversal of alkylation damage to DNA; primarily 1-methyladenine (1mA) and 3-methylcytosine (3mC) lesions created by endogenous or environmental alkylating agents. AlkB is a member of the non-heme iron (II) α-ketoglutarate-dependent dioxygenase s...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175350/ https://www.ncbi.nlm.nih.gov/pubmed/18003660 http://dx.doi.org/10.1093/nar/gkm1031 |