Cargando…
A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein
The von Hippel-Lindau tumor suppressor protein (pVHL) is inactivated in the hereditary cancer syndrome von Hippel-Lindau disease and in the majority of sporadic renal carcinomas. pVHL is the substrate-binding subunit of the CBC(VHL) ubiquitin ligase complex that negatively regulates cell growth by p...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175351/ https://www.ncbi.nlm.nih.gov/pubmed/17986458 http://dx.doi.org/10.1093/nar/gkm932 |