A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein

The von Hippel-Lindau tumor suppressor protein (pVHL) is inactivated in the hereditary cancer syndrome von Hippel-Lindau disease and in the majority of sporadic renal carcinomas. pVHL is the substrate-binding subunit of the CBC(VHL) ubiquitin ligase complex that negatively regulates cell growth by p...

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Detalles Bibliográficos
Autores principales: Bex, Claudia, Knauth, Katja, Dambacher, Silvia, Buchberger, Alexander
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175351/
https://www.ncbi.nlm.nih.gov/pubmed/17986458
http://dx.doi.org/10.1093/nar/gkm932

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