Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres

The activation of a telomere maintenance mechanism is required for cancer development in humans. While most tumors achieve this by expressing the enzyme telomerase, a fraction (5–15%) employs a recombination-based mechanism termed alternative lengthening of telomeres (ALT). Here we show that loss of...

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Detalles Bibliográficos
Autores principales: Grudic, Amra, Jul-Larsen, Åsne, Haring, Stuart J., Wold, Marc S., Lønning, Per Eystein, Bjerkvig, Rolf, Bøe, Stig Ove
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175364/
https://www.ncbi.nlm.nih.gov/pubmed/17959650
http://dx.doi.org/10.1093/nar/gkm738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175364/
https://www.ncbi.nlm.nih.gov/pubmed/17959650
http://dx.doi.org/10.1093/nar/gkm738

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