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A versatile method for the preparation of conjugates of peptides with DNA/PNA/analog by employing chemo-selective click reaction in water

The specific 1,3 dipolar Hüisgen cycloaddition reaction known as ‘click-reaction’ between azide and alkyne groups is employed for the synthesis of peptide–oligonucleotide conjugates. The peptide nucleic acids (PNA)/DNA and peptides may be appended either by azide or alkyne groups. The cycloaddition...

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Detalles Bibliográficos
Autores principales: Gogoi, Khirud, Mane, Meenakshi V., Kunte, Sunita S., Kumar, Vaijayanti A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175367/
https://www.ncbi.nlm.nih.gov/pubmed/17981837
http://dx.doi.org/10.1093/nar/gkm935