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Hepatoma derived growth factor binds DNA through the N-terminal PWWP domain

BACKGROUND: Hepatoma Derived Growth Factor (HDGF) is a nuclear protein with nuclear targeting required for mitogenic activity. Recently we demonstrated that HDGF is a transcriptional repressor, but whether HDGF binds DNA, the specificity of DNA binding and what protein domain is required are still u...

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Detalles Bibliográficos
Autores principales: Yang, Jun, Everett, Allen D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176068/
https://www.ncbi.nlm.nih.gov/pubmed/17974029
http://dx.doi.org/10.1186/1471-2199-8-101