Anaphase-Promoting Complex/Cyclosome–Dependent Proteolysis of Human Cyclin a Starts at the Beginning of Mitosis and Is Not Subject to the Spindle Assembly Checkpoint

Cyclin A is a stable protein in S and G2 phases, but is destabilized when cells enter mitosis and is almost completely degraded before the metaphase to anaphase transition. Microinjection of antibodies against subunits of the anaphase-promoting complex/cyclosome (APC/C) or against human Cdc20 (fizzy...

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Detalles Bibliográficos
Autores principales: Geley, Stephan, Kramer, Edgar, Gieffers, Christian, Gannon, Julian, Peters, Jan-Michael, Hunt, Tim
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185534/
https://www.ncbi.nlm.nih.gov/pubmed/11285280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185534/
https://www.ncbi.nlm.nih.gov/pubmed/11285280

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