Repeat Length and RNA Expression Level Are Not Primary Determinants in CUG Expansion Toxicity in Drosophila Models

Evidence for an RNA gain-of-function toxicity has now been provided for an increasing number of human pathologies. Myotonic dystrophies (DM) belong to a class of RNA-dominant diseases that result from RNA repeat expansion toxicity. Specifically, DM of type 1 (DM1), is caused by an expansion of CUG r...

Descripción completa

Detalles Bibliográficos
Autores principales: Le Mée, Gwenn, Ezzeddine, Nader, Capri, Michèle, Aït-Ahmed, Ounissa
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186381/
https://www.ncbi.nlm.nih.gov/pubmed/18213375
http://dx.doi.org/10.1371/journal.pone.0001466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186381/
https://www.ncbi.nlm.nih.gov/pubmed/18213375
http://dx.doi.org/10.1371/journal.pone.0001466

Ejemplares similares