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Repeat Length and RNA Expression Level Are Not Primary Determinants in CUG Expansion Toxicity in Drosophila Models

Evidence for an RNA gain-of-function toxicity has now been provided for an increasing number of human pathologies. Myotonic dystrophies (DM) belong to a class of RNA-dominant diseases that result from RNA repeat expansion toxicity. Specifically, DM of type 1 (DM1), is caused by an expansion of CUG r...

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Detalles Bibliográficos
Autores principales:	Le Mée, Gwenn, Ezzeddine, Nader, Capri, Michèle, Aït-Ahmed, Ounissa
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186381/ https://www.ncbi.nlm.nih.gov/pubmed/18213375 http://dx.doi.org/10.1371/journal.pone.0001466

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