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Isotype commitment in the in vivo immune responses. I. Antigen- dependent specific and polyclonal plaque-forming cell responses by B lymphocytes induced to extensive proliferation
The random recombination and deletion hypothesis for the control of isotype commitment in antibody responses was directly tested in a serial transfer system in vivo. Normal or hyperimmune spleen cells were used in weekly serial transfers with antigen into irradiated recipients until clonal senescenc...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1982
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186784/ https://www.ncbi.nlm.nih.gov/pubmed/6809880 |