Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection

Hapten-immune mice are capable of rejecting syngeneic skin grafts that are derivatized with the relevant hapten, but only if the hapten is applied while the graft is "healing in." This model system was used to demonstrate that the hapten-specific immune effectors responsible for rejection...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1983
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186986/
https://www.ncbi.nlm.nih.gov/pubmed/6339670
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collection PubMed
description Hapten-immune mice are capable of rejecting syngeneic skin grafts that are derivatized with the relevant hapten, but only if the hapten is applied while the graft is "healing in." This model system was used to demonstrate that the hapten-specific immune effectors responsible for rejection are restricted by H-2 determinants of the recipient. Thus, haptens can be used in vivo as surrogate transplantation antigens for the study of immunopathogenic mechanisms in transplantation immunity.
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spelling pubmed-21869862008-04-17 Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection J Exp Med Articles Hapten-immune mice are capable of rejecting syngeneic skin grafts that are derivatized with the relevant hapten, but only if the hapten is applied while the graft is "healing in." This model system was used to demonstrate that the hapten-specific immune effectors responsible for rejection are restricted by H-2 determinants of the recipient. Thus, haptens can be used in vivo as surrogate transplantation antigens for the study of immunopathogenic mechanisms in transplantation immunity. The Rockefeller University Press 1983-04-01 /pmc/articles/PMC2186986/ /pubmed/6339670 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection
title Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection
title_full Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection
title_fullStr Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection
title_full_unstemmed Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection
title_short Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection
title_sort haptens can serve as surrogate transplantation antigens in a manner that demonstrates h-2 restriction of graft rejection
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186986/
https://www.ncbi.nlm.nih.gov/pubmed/6339670

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