Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain

The highly selective cytotoxicity of site-directed ricin A chain conjugates can be potentiated by membrane-active carboxylic ionophores. The combined use of the two agents results in much faster inactivation of ribosomes and subsequent cell death and lysis. The potency of A chain cytotoxins is corre...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187464/
https://www.ncbi.nlm.nih.gov/pubmed/6090575
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collection PubMed
description The highly selective cytotoxicity of site-directed ricin A chain conjugates can be potentiated by membrane-active carboxylic ionophores. The combined use of the two agents results in much faster inactivation of ribosomes and subsequent cell death and lysis. The potency of A chain cytotoxins is correspondingly increased by several orders of magnitude and cells that sparsely express the target antigen or receptor can be killed.
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spelling pubmed-21874642008-04-17 Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain J Exp Med Articles The highly selective cytotoxicity of site-directed ricin A chain conjugates can be potentiated by membrane-active carboxylic ionophores. The combined use of the two agents results in much faster inactivation of ribosomes and subsequent cell death and lysis. The potency of A chain cytotoxins is correspondingly increased by several orders of magnitude and cells that sparsely express the target antigen or receptor can be killed. The Rockefeller University Press 1984-10-01 /pmc/articles/PMC2187464/ /pubmed/6090575 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain
title Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain
title_full Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain
title_fullStr Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain
title_full_unstemmed Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain
title_short Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain
title_sort carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin a chain
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187464/
https://www.ncbi.nlm.nih.gov/pubmed/6090575

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