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Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin)
Granules isolated from CTL and NK cells contain a cytolytic pore- forming protein (PFP/perforin). At low temperatures (on ice), PFP binds to erythrocyte membranes without producing hemolysis. Hemolysis occurs when the PFP-bound erythrocytes are warmed up to 37 degrees C, which defines a temperature-...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1987
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188309/ https://www.ncbi.nlm.nih.gov/pubmed/3494808 |