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Heavy-chain class switch does not terminate somatic mutation

We studied the H-chain class switch rearrangement in four groups of clonally related B cell hybridomas, to test the hypothesis that class switch terminates somatic mutation in a B cell. Using switch region- specific probes in Southern blot analysis individual mu-gamma switch rearrangement events can...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188341/
https://www.ncbi.nlm.nih.gov/pubmed/2115570