Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes

Human rTNF/Cachectin was shown to stimulate gene transcription of plasminogen activator inhibitor (PA1)-1 and PAI-2, and simultaneously suppress constitutive gene expression of tissue-type plasminogen activator (t-PA) in human fibrosarcoma cells. We propose that a TNF- mediated reprogramming of gene...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188989/
https://www.ncbi.nlm.nih.gov/pubmed/3137305
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collection PubMed
description Human rTNF/Cachectin was shown to stimulate gene transcription of plasminogen activator inhibitor (PA1)-1 and PAI-2, and simultaneously suppress constitutive gene expression of tissue-type plasminogen activator (t-PA) in human fibrosarcoma cells. We propose that a TNF- mediated reprogramming of gene transcription induces, in appropriate target cells, an anti-fibrinolytic state, which may cooperate with the induction of procoagulant activity (tissue factor) to stabilize the fibrin deposits commonly found in inflamed tissue. PAI genes also provide a model system for a study of the molecular pathways underlying TNF-mediated signal transduction.
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spelling pubmed-21889892008-04-17 Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes J Exp Med Articles Human rTNF/Cachectin was shown to stimulate gene transcription of plasminogen activator inhibitor (PA1)-1 and PAI-2, and simultaneously suppress constitutive gene expression of tissue-type plasminogen activator (t-PA) in human fibrosarcoma cells. We propose that a TNF- mediated reprogramming of gene transcription induces, in appropriate target cells, an anti-fibrinolytic state, which may cooperate with the induction of procoagulant activity (tissue factor) to stabilize the fibrin deposits commonly found in inflamed tissue. PAI genes also provide a model system for a study of the molecular pathways underlying TNF-mediated signal transduction. The Rockefeller University Press 1988-08-01 /pmc/articles/PMC2188989/ /pubmed/3137305 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes
title Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes
title_full Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes
title_fullStr Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes
title_full_unstemmed Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes
title_short Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes
title_sort plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188989/
https://www.ncbi.nlm.nih.gov/pubmed/3137305

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