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Reconstruction of the immunogenic peptide RNase(43-56) by identification and transfer of the critical residues into an unrelated peptide backbone
The involvement of each of the amino acid residues of the I-Ak- restricted T cell determinant RNase(43-56) was examined in detail using a series of peptides containing single amino acid substitutions. Four positions were identified as being essential for the formation of the determinant, Phe-46, Val...
Formato: | Texto |
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Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1989
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189390/ https://www.ncbi.nlm.nih.gov/pubmed/2473159 |