In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005]

The T cell lymphoma line BW5147 has rearranged TCR alpha chain genes segments on both the homologous chromosomes: one is functional (V alpha 1) and the second (V alpha 16.1) is a pseudogene. The extreme 3' position of the V alpha 16.1 gene segment in the V alpha locus allows us to recognize rea...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189552/
https://www.ncbi.nlm.nih.gov/pubmed/2555431
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collection PubMed
description The T cell lymphoma line BW5147 has rearranged TCR alpha chain genes segments on both the homologous chromosomes: one is functional (V alpha 1) and the second (V alpha 16.1) is a pseudogene. The extreme 3' position of the V alpha 16.1 gene segment in the V alpha locus allows us to recognize rearrangements of most V alpha gene segments using the V alpha 16 probe as a marker. The absence of the genomic V alpha 16.1 gene fragment in mature thymocytes, antigen-specific T cells, and in more than two-thirds of the peripheral T cells suggests that most T lymphocytes rearrange both alpha loci. It appears that productive alpha chain rearrangement on one allele probably does not block a subsequent rearrangement on the other alpha locus.
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spelling pubmed-21895522008-04-17 In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005] J Exp Med Articles The T cell lymphoma line BW5147 has rearranged TCR alpha chain genes segments on both the homologous chromosomes: one is functional (V alpha 1) and the second (V alpha 16.1) is a pseudogene. The extreme 3' position of the V alpha 16.1 gene segment in the V alpha locus allows us to recognize rearrangements of most V alpha gene segments using the V alpha 16 probe as a marker. The absence of the genomic V alpha 16.1 gene fragment in mature thymocytes, antigen-specific T cells, and in more than two-thirds of the peripheral T cells suggests that most T lymphocytes rearrange both alpha loci. It appears that productive alpha chain rearrangement on one allele probably does not block a subsequent rearrangement on the other alpha locus. The Rockefeller University Press 1989-12-01 /pmc/articles/PMC2189552/ /pubmed/2555431 Text en Copyright © 1989, https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ).
spellingShingle Articles
In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005]
title In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005]
title_full In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005]
title_fullStr In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005]
title_full_unstemmed In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005]
title_short In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005]
title_sort in individual t cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by hood l, urban jl. in: j exp med 1990 sep 1;172(3):1005]
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189552/
https://www.ncbi.nlm.nih.gov/pubmed/2555431

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