Reversal of the Ras-Induced Transformed Phenotype by Hr12, a Novel Ras Farnesylation Inhibitor, Is Mediated by the Mek/ERK Pathway

We have used the selective farnesylation inhibitor HR12 [cysteine-N(methyl)valine-N(cyclohexyl) glycine-methionine-O-methyl-ester] to study the role of oncogenic Ras in cytoskeletal reorganization in Ha-ras (V12)-transformed Rat1 cells (Rat1/ras). Application of HR12 resulted in complete restoration...

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Detalles Bibliográficos
Autores principales: Reuveni, Hadas, Geiger, Tamar, Geiger, Benjamin, Levitzki, Alexander
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190591/
https://www.ncbi.nlm.nih.gov/pubmed/11121434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190591/
https://www.ncbi.nlm.nih.gov/pubmed/11121434

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