Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements

Symmetries in the p53 response-element (p53RE) encode binding modes for p53 tetramer to recognize DNA. We investigated the molecular mechanisms and biological implications of the possible binding modes. The probabilities evaluated with molecular dynamics simulations and DNA sequence analyses were fo...

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Detalles Bibliográficos
Autores principales: Ma, Buyong, Levine, Arnold J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190717/
https://www.ncbi.nlm.nih.gov/pubmed/17986463
http://dx.doi.org/10.1093/nar/gkm890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190717/
https://www.ncbi.nlm.nih.gov/pubmed/17986463
http://dx.doi.org/10.1093/nar/gkm890

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